Dental Revolution in the Making

Dental Revolution in the Making

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Hi, Madina here, and welcome back to Stem Cell Talks. Today we want to update you on some exciting news in tooth regeneration technology using stem cells. Now as you may remember from our blogs we’ve discussed several studies that have used dental mesenchymal stem cells but if you have not here’s some of the most prominent ones. Researchers at Tufts University School of Dental Medicine have been using human dental stem cells to regrow teeth. Now this method involves placing stem cells in a gel scaffold to grow “tooth buds” that resemble the buds that children normally have below their deciduous teeth also known as baby teeth. The stem cell-grown buds are then implanted into the jawbone where they grow into fully-fledged adult teeth. This technique has been successfully tested in pigs. A similar study was conducted in Japan using epithelial and dental stem cells to not only grow the tooth bud but also the supporting tissues. In this particular study the teeth grew from buds into fully fledged teeth in just five months and additional tests confirm that the regrown teeth responded to orthodontic forces the same way a normal tooth would. This technique was successfully tested in canines. In a recent human study conducted at the University of Pennsylvania stem cells from deciduous teeth have restored damaged permanent teeth. Now as is often the case children injure their teeth by chipping them and the subsequent damage becomes significant over time as the tooth can become discolored, lose sensation, and eventually require extraction. Researchers used dental pulp stem cells from healthy deciduous teeth and seeded them into the damaged tooth, which had already lost sensation. In long-term follow-ups, the researchers noticed both a return of sensation in the damaged tooth and dentin regeneration. Additionally, the stem cells used were the patient’s own stem cells which eliminated the risk of rejection entirely. Stem cells and regenerative medicine are on the cusp of revolutionizing dentistry and innovating the standard of care with replacing artificial solutions with natural ones. The two animal studies were conducted on pigs and canines which are larger model organisms that are more physiologically similar to humans and the human trials predict where medicine will be heading in the near future. These treatments are also poised to offer personalized care by using autologous stem cells and highlight the pertinence of stem cell banking as an important component of the expanding health spans that the youth of today can expect in their lifetimes. Thank you for watching! Don’t forget to like us and to subscribe and we’ll see you again soon! you

12 thoughts on “Dental Revolution in the Making”

  1. I am a perfect candidate for this stem cell treatment. How can I set up a consultation to determine whether or not I can be included in this case study?

  2. What is knowingly ignored each time is that it takes a lot of time, considering that a human tooth takes about 5 years to develop and not 2 months as "scientists" would like us to believe. In contrast, for 15 years now we have been able to place a root-shaped immediate implant in less than a minute ( see BioImplant on YouTube).

  3. I had crowns placed on 8 of my teeth five years ago. I have been in a lot of pain since then. I feel very limited as a person from what I was before. Is there a way I can sign up for a trial to regrow my teeth?? Is there info about when trials might be available? I would do whatever it takes. I don't want to live the rest of my life in pain.

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